O’Connor et al. demonstrated with a high-throughput assays based on the use of flow cytometry that:
1) MOGAD patient sera can cause damage on MOG-expressing cells by multiple mechanism which includes complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP)
2) not all sera with anti-MOG antibodies induce cytotoxicity
3) cytotoxicity is not only related to antibody titre, and is greater closer to the relapse
4) there is concordance between the histopathological lesions of MOGAD and the quantification of CDC and ADCP
This cutting-edge study is extremely relevant because it has expanded knowledge on MOG autoantibodies and opened new horizons on the possible use of functional assays measuring CDC and ADCD as predictors of relapse in patients with MOGAD.